top of page
Enzyme_2E2Q_teal_50_transparency (1).png

Superior Proteins, By Design.

Our platform is powered by evolution, physics, and AI to design accurate, high-performance proteins, fast. Trusted by leading pharmaceutical and chemical companies

Ab_same (1).png

Among Our Partners

Teva logo.png
Ribbonbio logo.webp
Repsol 2 logo.png
ambrosia bio logo.png
Boehringer_Logo_RGB_Dark-Green.png
WeizmannLogo-300x114.gif

Trusted by:

1_edited.png
1200px-Teva_Pharmaceuticals_logo.png
2.png
group_1262x_1.png
Untitled design (10).png
3.jpg
Enzyme_2E2Q_teal_50_transparency (1).png
Ab_same (1).png

Superior Proteins, By Design.

Our platform is powered by evolution, physics,

and AI to design accurate, high-performance proteins, fast.

Trusted by leading pharmaceutical and chemical companies.

Our validation:

+130

Scientific

publications

+80

Research

labs

⁠Among our partners:

Intel_logo_(2006-2020).svg.png
Weizmann_new_logo_2023.png
Ribbonbio logo.webp
ambrosia bio logo_edited.png
Repsol 2 logo.png
Boehringer_Logo_RGB_Dark-Green (1).png
Intel_logo_(2006-2020).svg.png
Weizmann_new_logo_2023.png
Ribbonbio logo.webp
Teva API.webp
ambrosia bio logo_edited.png
Repsol 2 logo.png
Boehringer_Logo_RGB_Dark-Green (1).png

⁠Among our partners:

⁠Among our partners:

1_edited.png
1200px-Teva_Pharmaceuticals_logo.png
2.png
group_1262x_1.png
Untitled design (10).png

HOW IT WORKS

ScalaOS

ScalaOS designs superior proteins with greater speed and accuracy, resulting in shorter time to market and higher success rates.

Our software platform fuses atomistic calculations, evolutionary data, and AI modeling to generate high-performance proteins in a single design roundWe introduce dozens of beneficial mutations at once, significantly improving protein stability and activity while avoiding repeated iterations.

Whether you're designing an enzyme, an antibody, or any other protein, ScalaOS delivers faster, more reliable results.

Use our software or partner with us to design your protein:

HOW IT WORKS

ScalaOS

ScalaOS designs superior proteins with greater speed and accuracy, resulting in shorter time to market and higher success rates.

Our platform combines atomistic modeling, evolutionary data, and AI to create high performance proteins in a single design round, introducing multiple beneficial mutations to enhance stability and activity without repeated cycles.

HOW IT WORKS

ScalaOS

ScalaOS designs superior proteins faster and more accurately, reducing time to market and boosting success rates. 

Our platform combines atomistic modeling, evolutionary data, and AI to create high performance proteins in a single design round, introducing multiple beneficial mutations to enhance stability and activity without repeated cycles.

From enzymes to antibodies, ScalaOS delivers faster, more reliable protein design.

Use our software or partner with us to design your protein:

Our academic

validation:

>130

Scientific

publications

>80

research

labs

OUR MISSION

Designing superior proteins with
greater speed and precision,
accelerating time to market and
boosting success rates

OUR PLATFORMS

Enhancing Proteins Production & Stability

✦  Enabling expression in simple organisms (bacteria, yeast)

✦  Increasing production yields

✦  Thermostability, resilience to organic solvents or pH, shelf-life

✦  Multiple enzymes as starting points

Optimizing
Enzymes Activity

✦  Improving catalytic activity

✦  Increasing enzyme specificity

✦  Altering regio & enantio-selectivity

✦  Panels of diverse enzymatic activities

Therapeutic Antibody Optimization

​✦  Developability optimization

✦  Manufacturability

✦  Humanization / Murinization 

** Compatible with multiple antibody modalities (e.g. ADCs, bispecifics)

SUCCESS STORIES

ENZYME STABILITY
Design of a Challenging Drug Target

Enzymes for Biocatalysis

THE CHALLANGE

Highly dynamic and unstable
drug target. Cannot be produced in E. coli.

OUR SOLUTION
  • Single design round

  • 50 variants

  • 10-41 mutations in each

VACCINES
Design of a Malaria Vaccine Candidate 

Biotherapeutics

THE CHALLENGE

Cheap production of RH5 in
bacteria (replacing insects).
Ambient temp. Transport.

OUR SOLUTION
  • Single design round

  • 3 variants

  • 15-25 mutations in each

Enzyme Activity
Increasing conversion x7 in a single round

Enzymes for Biocatalysis

THE CHALLANGE

Enabling a cytochrome P450 enzyme to efficiently process a much smaller substrate beyond its natural capacity.

OUR SOLUTION
  • Single design round

  • 30 variants

  • 3-4 mutations in each

Therapeutic enzymes
Preclinical validation for neuronal Gaucher

Biotherapeutics

THE CHALLANGE

Inherent instability of glucocerebrosidase (GCase), limiting therapeutic efficacy for neuronal Gaucher disease.

OUR SOLUTION
  • Single design round

  • 8 variants

  • 35-72 mutations in each

What We Do

movie3.gif

At Scala Biodesign, we develop computational protein design technologies to optimize enzymes, antibodies, therapeutic proteins, and antigens across diverse industries.

 

Our proven in silico platforms integrate structure-based and sequence-based calculations, delivering faster, more reliable solutions to complex protein engineering challenges, all in a single design round.

 

Whether you're developing novel biocatalysts for green chemistry, designing complex antigens, or optimizing biologics and vaccines, ScalaOS, our cloud-based platform, empowers you to accelerate R&D while reducing time and costs.

Founding Team

Our founding team has over a decade of experience developing cutting-edge protein design methods. 

We established Scala to elevate protein design to the scale and reliability that are needed by the biotechnology and biopharmaceutical industries.

Intel Ignite 13.12-0214.jpg

Co-founder & CEO

Dr. Ravit Netzer

Intel Ignite 13.12-0172.jpg

Co-founder & CTO

Dr. Adi Goldenzweig

15270F04 (2).jpg

Chief scientist

Prof. Sarel Fleishman

OUR TEAM

IMG_3140_edited.jpg

The Founding Team

Ravit_color.png

Dr. Ravit Netzer

LI-In-Bug_edited_edited_edited_edited.png

Co-founder & CEO

Adi_color.png

Dr. Adi Goldenzweig

LI-In-Bug_edited_edited_edited_edited.png

Co-founder & CTO

Sarel_color.png

Prof. Sarel Fleishman

LI-In-Bug_edited_edited_edited_edited.png

Chief Scientist

Our founding team has over a decade of experience developing cutting-edge protein design methods

We established Scala to elevate protein design to the scale and reliability that are needed by the biotechnology and biopharmaceutical industries

SUCCESS STORIES

Let's Talk

Contact us today to discuss your scientific needs.

Vector-Email-Icon-PNG-Picture.png
bottom of page